Thiophosgene → 3-Phenoxyphenylisothiocyanate

HRID 13530

Reaktionsgleichung

Reaktionsgleichung von HRID 13530
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 10040ThiophosgeneHCID 771353-PhenoxyanilineHCID 21226206Ethyl acetate hexane

Produkt 1

HCID 220412813-Phenoxyphenylisothiocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.

Aufarbeitung

  1. customthe resulting reaction
  2. temperaturemaintained for 30 min
  3. concentrationThe reaction was concentrated
  4. customazeotroped with toluene
  5. customtaken on without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b272333b6f17485f927833b273755ad7
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728010B2

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