Thiazolidinedione → 5-[(3-Phenoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

HRID 1360984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360984
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].C([O-])(=O)C.[NH4+].[O:13]([C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH:23]=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(=O)C>[O:13]([C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH:23]=[C:5]1[S:1][C:2](=[O:7])[NH:3][C:4]1=[O:6])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Komponenten

5

Edukt 3

HCID 5437ThiazolidinedioneHCID 382843-PhenoxybenzaldehydeHCID 517165Ammonium Acetate

Produkt 1

HCID 28540035-[(3-Phenoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

A solution of thiazolidine-2,4-dione (90%, 78 mg, 0.6 mmol) and ammonium acetate (92 mg, 1.2 mmol) in acetic acid (1 mL) was added to 3-phenoxybenzaldehyde (52 μL, 0.6 mmol) and the resulting mixture was shaken at 115° C. for 16 hours. After cooling, the mixture was concentrated in vacuo to afford the title compound.

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ea3a5e1809b74e2e8c00deee8d274831
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879893B2

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