Thiazolidinedione → HCID 76545899, Verbindung

HRID 1360996Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360996
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[CH:8]([C:10]1[CH:22]=[CH:21][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=1)=O.C([O-])(=O)C.[Na+]>C(O)(=O)C>[O:7]=[C:2]1[NH:3][C:4](=[O:6])[C:5](=[CH:8][C:10]2[CH:22]=[CH:21][C:13]([O:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=2)[S:1]1

Komponenten

5

Edukt 3

HCID 5437ThiazolidinedioneHCID 517045Sodium AcetateHCID 35191904-(4-formylphenoxy)butanoic Acid

Produkt 1

HCID 76545899HCID 76545899, VerbindungAusbeute 32,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Thiazolidine-2,4-dione (3.55 g, 27.6 mmol), 4-(4-formylphenoxy)butyric acid (5.74 g, 27.6 mmol), anhydrous sodium acetate (11.3 g, 138 mmol) and acetic acid (100 mL) was refluxed for 16 h. After cooling, the mixture was filtered and washed with acetic acid and water. Drying in vacuo afforded 2.74 g (32%) of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenoxy]butyric acid as a solid.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe mixture was filtered
  3. washwashed with acetic acid and water
  4. customDrying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d0a2eccdb8d84dcdac3babf420c28868
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879893B2

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