Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide
Reaktionsgleichung
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>CC(O)=O>[BrH:1].[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][C:7]([Br:1])=[CH:6][N:5]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Bromine (1.1 mL, 20 mmol) in HOAc (20 mL) was added dropwise to a solution of 2-amino-pyridine-3-carbaldehyde (2.5 g, 20 mmol) in HOAc (50 mL) while stirring. After the addition, the mixture was allowed to stir for 2 h at room temperature. The precipitate was collected by filtration and washed with diethyl ether to afford the title compound (4.4 g, 77%) as a pale yellow solid: MS (ESI) m/e 201 (M+H)+.
Aufarbeitung
- additionAfter the addition
- stirringto stir for 2 h at room temperature
- filtrationThe precipitate was collected by filtration
- washwashed with diethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-ba7f4ab0eeae41a5a20858331f3db4bd
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07879872B2
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