Nitric Acid → 2-(2,5-Dimethoxy-4-nitrophenyl)acetic acid

HRID 1364551

Reaktionsgleichung

Reaktionsgleichung von HRID 1364551
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13].[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:15]([O-:17])=[O:16])[C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13]

Komponenten

5

Edukt 2

HCID 944Nitric AcidHCID 744692,5-Dimethoxyphenylacetic acid

Produkt 1

HCID 123157582-(2,5-Dimethoxy-4-nitrophenyl)acetic acidAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of of 2,5-dimethoxyphenylacetic acid (1.00 g, 5.10 mmol) in 10 mL of acetic acid was added 6.5 mL of 1.0M HNO3 in acetic acid. The reaction was stirred at ambient temperature for 10 min, and diluted with 75 mL of water. The yellow precipitate was collected and washed with water (3×10 mL), then dried on the filter. Recrystallization from 20 mL of 2-propanol gave 846 mg (69%) of the titled compound as fine yellow crystals.

Aufarbeitung

  1. customThe yellow precipitate was collected
  2. washwashed with water (3×10 mL)
  3. customdried on the filter
  4. customRecrystallization from 20 mL of 2-propanol

Quellen und Nachweise

ORD-Eintrag
ord-1b6198da01a148ad9b38abc99bb3f0bf
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888374B2

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