Ammonium formate → N-(5-aminopyridin-2-yl)-2-phenylacetamide

HRID 1366196

Reaktionsgleichung

Reaktionsgleichung von HRID 1366196
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:8][CH:9]=1)([O-])=O.C([O-])=O.[NH4+]>CCO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11](=[O:19])[CH2:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[N:8][CH:9]=1

Komponenten

6

Edukt 2

HCID 2723923Ammonium formateHCID 4350143N-(5-nitropyridin-2-yl)-2-phenylacetamide

Produkt 1

HCID 43144587N-(5-aminopyridin-2-yl)-2-phenylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of N-(5-nitropyridin-2-yl)-2-phenylacetamide (4.35 g, 16.9 mmol) in EtOH (75 mL) and EtOAc (75 mL) is stirred at rt and ammonium formate (4.27 g) and 10% Pd/C (500 mg) are added. The mixture is heated at reflux for 30 min, cooled, filtered through celite and evaporated to afford the title compound as an off-white solid which was used without further purification.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 30 min
  3. temperaturecooled
  4. filtrationfiltered through celite
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-196008d43ba04aa4a74677cbf4558bf4
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07893058B2

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