HCID 22018329, Verbindung → HCID 178458193, Verbindung
Reaktionsgleichung
[CH:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)([CH3:3])[CH3:2]>C(O)(=O)C.O>[CH:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)([CH3:2])[CH3:3]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
1-(6-Isopropoxynaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (0.438 g) was dissolved in a mixture of acetic acid (20 ml) and water (0.5 ml), and the solution was stirred at 50° C. for 18 h. The solvent was evaporated, and to the mixture was added ethyl acetate. The mixture was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution. The organic layer was dried and concentrated. The obtained residue was purified by silica gel column chromatography (eluent, dichloromethane:methanol=40:1→20:1) to give the titled compound (0.170 g) as an amorphous product.
Aufarbeitung
- customThe solvent was evaporated
- additionto the mixture was added ethyl acetate
- washThe mixture was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution
- customThe organic layer was dried
- concentrationconcentrated
- customThe obtained residue was purified by silica gel column chromatography (eluent, dichloromethane:methanol=40:1→20:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-c51d8eb8d17e4290ab134e3548f294cd
- Quelldatensatz
- uspto-grants-2003_06
- Patentnummer
- US06573289B1
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