Malonic Acid → 3-Amino-3-(3-methylphenyl)propanoic acid

HRID 1371531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371531
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[C:10]([OH:16])(=[O:15])[CH2:11]C(O)=O.C([O-])(=O)C.[NH4+:21]>COCCO>[NH2:21][CH:5]([C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([CH3:1])[CH:3]=1)[CH2:11][C:10]([OH:16])=[O:15]

Komponenten

5

Edukt 3

HCID 867Malonic AcidHCID 121053-MethylbenzaldehydeHCID 517165Ammonium Acetate

Produkt 1

HCID 27642983-Amino-3-(3-methylphenyl)propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

11.8 ml of 3-methylbenzaldehyde are added to a mixture of 10.4 g of malonic acid and 15.4 g of ammonium acetate in 150 ml of 2-methoxyethanol, and the mixture is heated overnight at 80° C. After cooling to RT, the precipitate formed is filtered off under suction, washed with ether and dried. 6.8 g of the expected product are obtained.

Aufarbeitung

  1. temperatureAfter cooling to RT
  2. customthe precipitate formed
  3. filtrationis filtered off under suction
  4. washwashed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5a501653de8a4fa78aac7f124847d97a
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157454B2

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