1,2-Dichloroethane → (5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-difluoromethyl-2-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

HRID 137413

Reaktionsgleichung

Reaktionsgleichung von HRID 137413
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([NH2:23])[cH:22]2)[CH2:11][O:10][CH:9]1[CH3:25])=[O:26].[C:27](#[N:28])[c:29]1[cH:30][cH:31][c:32]([C:35](=[O:36])[OH:37])[n:33][cH:34]1.[CH2:38]([Cl:39])[CH2:40][Cl:41].[CH:42]([N:43]([CH2:44][CH3:45])[CH:46]([CH3:47])[CH3:48])([CH3:49])[CH3:50].[O:51]=[CH:52][N:53]([CH3:54])[CH3:55]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([NH:23][C:35]([c:32]3[cH:31][cH:30][c:29]([C:27]#[N:28])[cH:34][n:33]3)=[O:36])[cH:22]2)[CH2:11][O:10][CH:9]1[CH3:25])=[O:26]

Komponenten

6

Edukt 5

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 124007345-Cyanopyridine-2-carboxylic acidHCID 66665672[5-(5-amino-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Produkt 1

HCID 66665624(5-{5-[(5-Cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-difluoromethyl-2-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

Quellen und Nachweise

ORD-Eintrag
ord-7e34c530bc8a45e28c70b7862a44338a
Quelldatensatz
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

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