Triethylamine → HCID 67214572, Verbindung

HRID 1375597Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1375597
C(OP(C#[N:10])(=O)OCC)C.[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]3[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=3)[C:27]([OH:29])=O)[N:18]=2)[CH:12]=1.[CH3:33][N:34]1[CH2:39][CH2:38][N:37]([CH2:40]C2C=CC(N)=CC=2)[CH2:36][CH2:35]1.C(N(CC)CC)C.C(=O)([O-])O.[Na+]>CN(C)C=O.O>[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]3[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=3)[C:27]([NH:10][CH2:40][N:37]3[CH2:36][CH2:35][N:34]([CH3:33])[CH2:39][CH2:38]3)=[O:29])[N:18]=2)[CH:12]=1

Komponenten

8

Edukt 5

HCID 8471TriethylamineHCID 76257Diethyl cyanophosphonateHCID 516892Sodium BicarbonateHCID 31539964-((4-Methylpiperazin-1-yl)methyl)anilineHCID 10039959HCID 10039959, Verbindung

Produkt 1

HCID 67214572HCID 67214572, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Diethylcyanophosphonate (Aldrich, Buchs, Switzerland; 0.50 mL, 3.0 mmol) is added to a stirred mixture of 3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzoic acid (438 mg, 1.5 mmol), 4-[(4-methyl-1-piperazinyl)methyl]benzeneamine (308 mg, 1.5 mmol) and triethylamine (840 μL, 3.0 mmol) in 10 mL N,N-dimethylformamide at 10° C. After stirring for 12 hours at 60° C., the mixture is treated with an aqueous solution of sodium hydrogen carbonate and extracted three times with ethyl acetate. The combined extracts are washed with water, and the solvent is evaporated off under reduced pressure to give a residue. The residue is resuspended in water and filtered to afford the crude product which is recrystallised from tetrahydrofuran-ethyl acetate to give N-[3-[[4-(3-Pyridinyl)-2-pyrimidinyl]amino]-N-[(4-methyl-1-piperazinyl)-methyl]benzamide as a crystalline solid, m.p. 220–224° C.

Aufarbeitung

  1. extractionextracted three times with ethyl acetate
  2. washThe combined extracts are washed with water
  3. customthe solvent is evaporated off under reduced pressure
  4. customto give a residue
  5. filtrationfiltered
  6. customto afford the crude product which
  7. customis recrystallised from tetrahydrofuran-ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-57c2a69b6f2744c5be062ea588287333
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07169791B2

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