Acetic Acid → phenyl-(2-(1-Boc-4-piperidinylamino)phenyl) carbinol

HRID 1377697

Reaktionsgleichung

Reaktionsgleichung von HRID 1377697
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]([OH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:16]([N:23]1[CH2:28][CH2:27][C:26](=O)[CH2:25][CH2:24]1)([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17].C(O)(=O)C.C([BH3-])#N.[Na+]>CO>[C:5]1([CH:4]([C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[NH:1][CH:26]2[CH2:27][CH2:28][N:23]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:24][CH2:25]2)[OH:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 2708102-AminobenzhydrolHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 5003444Sodium cyanoborohydride

Produkt 1

HCID 57083091phenyl-(2-(1-Boc-4-piperidinylamino)phenyl) carbinol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Aminobenzhydrol from Step 1 above (1.0 g, 5 mmol), N-Boc-4-piperidone (2.0 g, 10 mmol), and acetic acid (0.86 mL, 0.9 g, 15 mmol) were combined in methanol (10 mL). Sodium cyanoborohydride (0.79 g, 12.5 mmol) was added in portions, and the mixture was stirred at ambient temperature for 42 hours. The mixture was concentrated in vacuo. Ethyl acetate (100 mL) was added to the residue and the resulting mixture was washed with saturated aqueous sodium bicarbonate, dried over sodium sulfate, filtered, and evaporated in vacuo. The residue was chromatographed on silica gel eluted with 1:9 then 15:85 EtOAc:hexane. The combined product fractions were evaporated to dryness in vacuo to give phenyl-(2-(1-Boc-4-piperidinylamino)phenyl) carbinol.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. additionEthyl acetate (100 mL) was added to the residue
  3. washthe resulting mixture was washed with saturated aqueous sodium bicarbonate
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customThe residue was chromatographed on silica gel
  8. washeluted with 1:9
  9. customThe combined product fractions were evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-739770d9196e453ca2ce9b4ac7dc3405
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05665719

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