Methanol → HCID 136332138, Verbindung

HRID 1380311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380311
[OH:1][N:2]=[C:3]([CH3:18])[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[C:11](=[O:17])[CH2:10][CH2:9]2)=O.[NH2:19][NH:20][C:21]([NH2:23])=[S:22].CO.O>C(O)(=O)C>[OH:1][N:2]=[C:3]([CH3:18])[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[C:11](=[O:17])[CH2:10][CH2:9]2)=[N:19][NH:20][C:21]([NH2:23])=[S:22]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 962WaterHCID 2723789ThiosemicarbazideHCID 73666243HCID 73666243, Verbindung

Produkt 1

HCID 136332138HCID 136332138, VerbindungAusbeute 26,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 6-(2-hydroxyiminopropionyl)-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline (1 g), thiosemicarbazide (0.48 g), methanol (10 ml), water (5 ml) and acetic acid (0.1 ml) was refluxed for 13 hours with stirring. After cooling, the resulting precipitates were collected by filtration, washed successively with ethanol, water and ethanol, and then dried to give 0.34 g of 6-(2-hydroxyimino-1-thiosemicarbazonopropyl)-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline.

Aufarbeitung

  1. temperaturewas refluxed for 13 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed successively with ethanol, water and ethanol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cd56ec2356cd43809b308a87e3d511e4
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04581356

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