Methyl 2-(Trifluoromethyl)-3,3,3-trifluoropropionate → Methyl 3,3,3-trifluoropropanoate

HRID 1380684

Reaktionsgleichung

Reaktionsgleichung von HRID 1380684
[F:1][C:2]([F:13])([F:12])[CH:3](C(F)(F)F)[C:4]([O:6][CH3:7])=[O:5].C([O-])(=O)C.[K+]>O>[F:1][C:2]([F:13])([F:12])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

Komponenten

4

Edukt 2

HCID 9673Methyl 2-(Trifluoromethyl)-3,3,3-trifluoropropionateHCID 517044Potassium Acetate

Produkt 1

HCID 2782392Methyl 3,3,3-trifluoropropanoateAusbeute 76,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of 105 g (0.5 mol) of methyl 2-(trifluoromethyl)-3,3,3-trifluoropropionate in 250 ml of water, a solution of 150 g (1.5 mol) of potassium acetate in 500 ml of water was added dropwise and the mixture was refluxed for 5 hours. After separation of the oily layer, extraction was made from the water layer that was left using methylene chloride. The oily layer and extracted fraction were joined and dried. After evaporation of methylene chloride under atmospheric pressure, purification by distillation was performed to give methyl 3,3,3-trifluoropropionate (TFPE) (54.07 g, 76%). Its analysis gave the following data:

Aufarbeitung

  1. temperaturethe mixture was refluxed for 5 hours
  2. customAfter separation of the oily layer, extraction
  3. waitwas left
  4. extractionThe oily layer and extracted fraction
  5. customdried
  6. customAfter evaporation of methylene chloride
  7. customunder atmospheric pressure, purification
  8. distillationby distillation

Quellen und Nachweise

ORD-Eintrag
ord-6cee4cc35884419ab9867c4665dc8c4e
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04582924

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