Morpholine → 8-[2-Methoxy-4-(morpholine-4-sulfonyl)phenyl]-7H-purine

HRID 1380745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380745
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl.[CH3:8][O:9][C:10]1[CH:15]=[C:14]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=1[C:20]1[NH:28][C:27]2[C:22](=[N:23][CH:24]=[N:25][CH:26]=2)[N:21]=1>C(OCC)(=O)C.O>[CH3:8][O:9][C:10]1[CH:15]=[C:14]([S:16]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=1[C:20]1[NH:28][C:27]2[C:22](=[N:23][CH:24]=[N:25][CH:26]=2)[N:21]=1

Komponenten

5

Edukt 2

HCID 8083MorpholineHCID 20184500HCID 20184500, Verbindung

Produkt 1

HCID 132845378-[2-Methoxy-4-(morpholine-4-sulfonyl)phenyl]-7H-purine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

An amount of 0.8 ml of morpholine was dissolved in a two-phase mixture of 40 ml of ethyl acetate and 40 ml of water. Then, 1 gm of crude 8-(2'-methoxy-4'-chlorosulfonylphenyl)-purine hydrochloride was added thereto in batches, under vigorous stirring, and the resulting mixture was heated to 80° C. for two hours. The reaction mixture was concentrated down to one-third of the volume, and the crystals precipitated were subjected to suction filtration and washed with water.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated down to one-third of the volume
  2. customthe crystals precipitated
  3. filtrationwere subjected to suction filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-8b7759ebc5884582959a6fe823bedf15
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04582837

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