1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine → 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

HRID 1380956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380956
C([N:8]1[CH2:13][CH2:12][C:11]([C:26]([O:28][CH3:29])=[O:27])([N:14]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:15](=[O:17])[CH3:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)(=O)C>[CH3:29][O:28][C:26]([C:11]1([N:14]([O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:15](=[O:17])[CH3:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:27]

Komponenten

5

Edukt 2

HCID 233248381-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 233248214-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 12.45 g of 1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine and 250 ml of acetic acid is hydrogenated at room temperature and pressure with 1.5 g of 10% palladium-on-charcoal catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The acetic acid is flash evaporated, the residue is dissolved in toulene and stirred with 10 g of anhydrous sodium carbonate. The solid is filtered and the filtrate is flash evaporated to obtain 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine.

Aufarbeitung

  1. customis hydrogenated at room temperature
  2. filtrationthe catalyst is filtered off
  3. customevaporated
  4. dissolutionthe residue is dissolved in toulene
  5. filtrationThe solid is filtered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-cbccb428274b419395cd1469a0960944
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04584303

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