Methanethiol → 2-Methylthio-2,4-dimethylpentan-3-one

HRID 1382047

Reaktionsgleichung

Reaktionsgleichung von HRID 1382047
CO.[Na].[CH3:4][SH:5].Br[C:7]([CH3:14])([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[CH3:8]>O>[CH3:4][S:5][C:7]([CH3:14])([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[CH3:8]

Komponenten

6

Edukt 4

HCID 878MethanethiolHCID 887MethanolHCID 2225752-Bromo-2,4-dimethylpentan-3-oneHCID 5360545Sodium

Produkt 1

HCID 132479432-Methylthio-2,4-dimethylpentan-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 200 ml. of methanol containing 9.2 g. (0.40 mole) sodium metal was cooled in an ice-bath and saturated with gaseous methyl mercaptan. To this was added 77.2 g. (0.40 mole) of 2-bromo-2,4-dimethyl-pentan-3-one at room temperature and the resulting mixture stirred for two hours. The reaction mixture was diluted with water, extracted with ethyl ether, the extracts washed with water, brine and dried over anhydrous sodium sulfate. The ether was evaporated and the residue distilled in vacuo to afford 50.4 g. of product, B.P. 76° (20 mm.).

Aufarbeitung

  1. additionTo this was added 77.2 g
  2. extractionextracted with ethyl ether
  3. washthe extracts washed with water, brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe ether was evaporated
  6. distillationthe residue distilled in vacuo
  7. customto afford 50.4 g

Quellen und Nachweise

ORD-Eintrag
ord-b539443b8f764c2990f639993039dee7
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04804782

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