Methane → 5-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

HRID 1382719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1382719
[N:1]([C:4]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6][CH:5]=1)=[N+]=[N-].C>CO.[Pd]>[NH2:1][C:4]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 2

HCID 297MethaneHCID 14304685HCID 14304685, Verbindung

Produkt 1

HCID 132683465-Amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dioneAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.33 g of Compound 3 was dissolved in 400 ml of methanol and reduced in the presence of 300 mg of Pd-C. Activated charcoal powder was added, and the solution was heated and filtered. The filtrate was distilled under reduced pressure and ethanol added thereto. The resulting crude crystals were separated by filtration and recrystallized from ethanol to give 0.87 g of 5-amino-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 4).

Aufarbeitung

  1. temperaturethe solution was heated
  2. filtrationfiltered
  3. distillationThe filtrate was distilled under reduced pressure and ethanol
  4. additionadded
  5. customThe resulting crude crystals were separated by filtration
  6. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-791360420a244b76ab2a826578cbd435
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04808587

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