Hydrogen Bromide → 2-[3-(Methylamino)propyl]benzthiazole dihydrobromide

HRID 1382923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1382923
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13](C)[C:14](=O)OCC1C=CC=CC=1.CCOCC.[BrH:30]>C(O)(=O)C>[BrH:30].[BrH:30].[CH3:14][NH:13][CH2:12][CH2:11][CH2:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 53819401Benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate

Produkt 1

HCID 212734622-[3-(Methylamino)propyl]benzthiazole dihydrobromideAusbeute 93,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1.7 g (4.99 mmol) of benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate are dissolved at 0° in 40% hydrogen bromide in acetic acid and stirred at room temperature for 20 hours. Thereupon, 60 ml of ether are added and, after 1.5 hours, the precipitate formed is filtered off. After washing the crystalline precipitate with ether and drying there are obtained 1.71 g (93.1%) of 2-[3-(methylamino)propyl]benzthiazole dihydrobromide, m.p. 196°-197°.

Aufarbeitung

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washAfter washing the crystalline precipitate with ether
  4. customdrying there

Quellen und Nachweise

ORD-Eintrag
ord-42f63d39ede14e90ae2a9acd9c59d6b5
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04808605

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