Hydrogen Peroxide → HCID 14372165, Verbindung

HRID 1383009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1383009
[S:1]([C:5]1[O:13][C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].[OH:14]O.O>C(O)(=O)C>[S:1]([C:5]1[O:13][C:12]2[C:7](=[N+:8]([O-:14])[CH:9]=[CH:10][CH:11]=2)[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14372164Furo[3,2-b]pyridine-2-sulfonamide

Produkt 1

HCID 14372165HCID 14372165, VerbindungAusbeute 63,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a suspension of 2-sulfamoylfuro[3,2-b]pyridine (647 mg, 3.27 mmol) in glacial acetic acid (8 mL) was added 30% hydrogen peroxide (0.6 mL). This suspension was warmed at 60° C. for four hours to give a clear solution. Upon cooling the reaction mixture and adding water the product crystallized out. This pure product (444 mg, 63.5% yield) was collected by filtration, washed with water, ethanol and diethyl ether, mp: 236°-237° C. (decomposition).

Aufarbeitung

  1. customto give a clear solution
  2. temperatureUpon cooling the reaction mixture
  3. customcrystallized out

Quellen und Nachweise

ORD-Eintrag
ord-b71766f77c814328a55713543aafb0f8
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04808595

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