Acetic Acid → HCID 21717327, Verbindung

HRID 1386097Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386097
[CH2:1]([C:3]1[CH:4]=[C:5]([F:10])[CH:6]=[C:7](C)[CH:8]=1)[CH3:2].C=O.[BrH:13].[C:14](O)(=O)[CH3:15]>O>[CH2:1]([C:3]1[CH:4]=[C:5]([F:10])[CH:6]=[C:14]([CH3:15])[C:8]=1[CH2:7][Br:13])[CH3:2]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 712FormaldehydeHCID 217173603-Ethyl-1-fluoro-5-methylbenzene

Produkt 1

HCID 21717327HCID 21717327, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3-ethyl-1-fluoro-5-methylbenzene (1.1 g, 0.008 mol), paraformaldehyde (1.5 g, 0.05 mol), hydrobromic acid (4.1 ml 0.017 mol) (4.1 M in acetic acid) and acetic acid (2.5 ml) was stirred at ambient temperature for 40 h. To the mixture were water and petroleum ether (40-60) added and the organic layer was separated, washed with water, dried over anhydrous sodium sulfate and evaporated carefully under reduced pressure. The desired product was obtain as a yellow oil (1.3 g, 72%).

Aufarbeitung

  1. additionadded
  2. customthe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated carefully under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f20913f822b24e11b5cf58666fbb6e17
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265415B1

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