Water → 2-(4-Methylphenyl)quinazolin-4(3H)-one

HRID 1388236Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1388236
[C:1]([C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=O)(=[O:3])[NH2:2].[OH-].[Na+].O>C(O)(=O)C>[CH3:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]2[NH:2][C:1](=[O:3])[C:4]3[C:5](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:6]=2)=[CH:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 8196472-[(4-methylbenzoyl)amino]benzamide

Produkt 1

HCID 1354521092-(4-Methylphenyl)quinazolin-4(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 2'-carbamoyl-p-toluanilide (66.97 g; 0.263 mol), sodium hydroxide (41.9 g) and water 837 ml) is stirred and heated at reflux for 0.5 hour. The resultant solution is cooled down, made acid with acetic acid. The reaction mixture is filtered, the isolated product is washed and dried to afford 58.16 g off white solid, mp 239°-241° C. Recrystallized from absolute ethanol, the product has a mp of 239°-240.5° C.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 0.5 hour
  3. filtrationThe reaction mixture is filtered
  4. washthe isolated product is washed
  5. customdried
  6. customto afford 58.16 g off white solid, mp 239°-241° C
  7. customRecrystallized from absolute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f041c9964c7241bf930d40ac3ff617ab
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04431440

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