Sodium borohydride → 5-Chloro-2'-fluoro-2-iodobenzhydrol

HRID 1389035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389035
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=[O:8].[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[CH:7]([OH:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15]

Komponenten

5

Edukt 2

HCID 4311764Sodium borohydrideHCID 12948263(5-Chloro-2-iodophenyl)(2-fluorophenyl)methanone

Produkt 1

HCID 205631225-Chloro-2'-fluoro-2-iodobenzhydrol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 54 g (0.15 mole) of 5-chloro-2'-fluoro-2-iodobenzophenone and 28.4 g (0.75 mole) of sodium borohydride in 1000 ml of ethanol was stirred at 0° C. for 15 min. The solution was diluted with water and extracted with ether. The ether solution was washed with water, dried over anhydrous sodium sulfate, and concentrated at reduced pressure to give a deep yellow oil.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe ether solution was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated at reduced pressure
  5. customto give a deep yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-dfb3528e454a4f199fbe90932d4dc2ed
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04243589

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