Furan → 5-Chloro-1-(2-furyl)-1-pentanol

HRID 1389629

Reaktionsgleichung

Reaktionsgleichung von HRID 1389629
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[Li].C([Li])CCC.O1C=CC=C1.[Cl:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][OH:23].[Cl-].[NH4+]>CCOCC.C(Cl)Cl.CCCCCC>[Cl:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]([C:2]1[O:1][CH:5]=[CH:4][CH:3]=1)[OH:23]

Komponenten

9

Edukt 5

HCID 8029FuranHCID 25517Ammonium ChlorideHCID 789155-Chloro-1-pentanolHCID 178418296HCID 178418296, VerbindungHCID 178418339Butyllithium

Produkt 1

HCID 202925795-Chloro-1-(2-furyl)-1-pentanol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 3283Diethyl EtherLösungsmittel2×HCID 6344DichloromethaneLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

To a stirred suspension of 2-furyllithium (prepared from 0.53 moles of n-butyllithium and 39.5 g of furan by the procedure of J. Org. Chem., 27, 1216 (1962)) in 350 ml of ether and ca. 200 ml of hexane at -78° is added a solution of 57.9 g of 5-chloropentanol (Chem. Abstr., 59, 7579F (1963)) in 80 ml of ether during 25 minutes. The mixture is warmed to 0° during 20 minutes, stirred at 0° for 15 minutes, and treated with 140 ml of saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid, pmr spectrum (CDCl3): δ3.59 (triplet, CH2Cl2) and 4.70 (triplet, CH2CHOH).

Aufarbeitung

  1. temperatureThe mixture is warmed to 0° during 20 minutes
  2. washThe ether phase is washed with water and brine
  3. dry with materialdried over magnesium sulfate and potassium carbonate mixture
  4. concentrationconcentrated
  5. customto give a liquid, pmr spectrum (CDCl3)

Quellen und Nachweise

ORD-Eintrag
ord-fb32fe539e074f17aad79b901dd3649c
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04245121

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