Methanol → 2,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One

HRID 1395445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395445
[CH2:1]1[N:6]2[C:7]3[C:12]([NH:13][C:14](=[O:15])[CH:5]2[CH2:4][NH:3][CH2:2]1)=[CH:11][CH:10]=[CH:9][CH:8]=3.[CH:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[CH2:17].CO>C(O)(=O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:16][CH2:17][N:3]1[CH2:2][CH2:1][N:6]2[C:7]3[C:12]([NH:13][C:14](=[O:15])[CH:5]2[CH2:4]1)=[CH:11][CH:10]=[CH:9][CH:8]=3

Komponenten

5

Edukt 3

HCID 887MethanolHCID 75212-VinylpyridineHCID 1563622,3,4,4a-Tetrahydro-1H-pyrazino(1,2a)quinoxalin-5-(6H)one

Produkt 1

HCID 203394222,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one (7 g.) and 2-vinylpyridine (12 g.) in 150 ml. of methanol containing 5 ml. glacial acetic acid were heated under reflux for 24 hours. After removing solvent under reduced pressure, the residue was slurried with water and the insoluble material filtered off and washed with water. After drying there was obtained 9.3 g. of the title compound. A portion recrystallized from ethanol gave a m.p. of 167°-69° C.

Aufarbeitung

  1. temperatureunder reflux for 24 hours
  2. customAfter removing solvent under reduced pressure
  3. filtrationthe insoluble material filtered off
  4. washwashed with water
  5. customAfter drying there
  6. customwas obtained 9.3 g

Quellen und Nachweise

ORD-Eintrag
ord-a4c4040b93bf44aabe58085acaa7951e
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04203987

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