Hydrochloric Acid → HCID 20339419, Verbindung

HRID 1395459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395459
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3.O.Cl.[H][H]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 203394222,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-OneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 20339419HCID 20339419, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)-ethyl]-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one in 120 ml. water and 60 ml. ethanol containing 14 ml. conc. hydrochloric acid, was shaken with 1.2 g. of PtO2 under 45 psi. hydrogen pressure. Solution was filtered, concentrated under vacuum, and residue crystallized once from ethanol and then from methanol. After filtration and drying the dihydrochloride salt of the title compound had a m.p. of 268°-271° C. (dec.); yield: 3.5 g.

Aufarbeitung

  1. filtrationSolution was filtered
  2. concentrationconcentrated under vacuum, and residue
  3. customcrystallized once from ethanol
  4. filtrationAfter filtration
  5. dry with materialdrying the dihydrochloride salt of the title compound

Quellen und Nachweise

ORD-Eintrag
ord-b8dec87d938f4455b1c7ac8511c4e605
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04203987

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