Hydrochloric Acid → HCID 178509540, Verbindung

HRID 1404907Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1404907
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1Cl)[C:5]#[N:6].[C:11](=[S:16])(OCC)[S-:12].[K+].Cl>CN(C=O)C.O>[C:5]([C:4]1[CH:7]=[CH:8][C:9]2[S:12][C:11]([SH:16])=[N:1][C:2]=2[CH:3]=1)#[N:6]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 1044643-Amino-4-chlorobenzonitrileHCID 2735045Potassium ethylxanthate

Produkt 1

HCID 178509540HCID 178509540, VerbindungAusbeute 76,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

A mixture of 3-amino-4-chloro benzonitrile (13, 0.50 g, 3.28 mmol) and potassium O-ethyl dithiocarbonate (1.05 g, 6.55 mmol) in DMF (15 mL) was heated overnight at 110-120° C. under N2. After cooling, the reaction mixture was diluted with water and acidified with 1N HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to yield 14 (0.48 g, 76%).

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-58491280b04643bcbe6067d240e6a43f
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916550B2

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