Water → 3-{[(2-Furylmethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

HRID 14124

Reaktionsgleichung

Reaktionsgleichung von HRID 14124
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]([CH2:9][C:10]1[CH:11]=[C:12]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[C:13]([O:15]C)=[O:14])[CH3:8].O.[OH-].[Li+]>CO.O1CCCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]([CH2:9][C:10]1[CH:11]=[C:12]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[C:13]([OH:15])=[O:14])[CH3:8]

Komponenten

6

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086145Methyl 3-{[(2-furylmethyl)(methyl)amino]methyl}-5-methylbenzoate

Produkt 1

HCID 210856693-{[(2-Furylmethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 3-{[(2-furylmethyl)(methyl)amino]methyl}-5-methylbenzoate (180 mg, 0.66 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (277 mg, 6.6 mmol), and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound. ESI MS m/z 258 [M+H]+.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1253b6bd201640669ae0fb77cdf1d491
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

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