Water → HCID 54477182, Verbindung

HRID 1413083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413083
[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].O.[C:10](OC(=O)C)(=[O:12])[CH3:11]>N1C=CC=CC=1>[C:10]([O:1][C@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8])(=[O:12])[CH3:11]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 5289581(S)-3-hydroxypiperidin-2-one

Produkt 1

HCID 54477182HCID 54477182, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 460 mg of (S)-(-)-3-hydroxy-2-piperidone [A. Hunter, Biochemical Journal, 35, 1298 (1941); mp. 170°-171° C., [α]D26 =-3.0°±0.1° (c=7.027, H2O)] in 6 ml of pyridine is added 2 ml of acetic anhydride, and the mixture is allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue is crystallized from ether and then recrystallized from ether to give 560 mg of (S)-(-)-3-acetoxy-2-piperidone as pillar crystals in 89% yield.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. customThe residue is crystallized from ether
  3. customrecrystallized from ether

Quellen und Nachweise

ORD-Eintrag
ord-324b8e8ecaf7488990ccbd34135f998e
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04248865

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