Water → 3-{[Isobutyl(methyl)amino]methyl}-5-methylbenzoic acid

HRID 14134

Reaktionsgleichung

Reaktionsgleichung von HRID 14134
[CH2:1]([N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([O:13]C)=[O:12])[CH3:6])[CH:2]([CH3:4])[CH3:3].O.[OH-].[Li+]>CO.O1CCCC1>[CH2:1]([N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([OH:13])=[O:12])[CH3:6])[CH:2]([CH3:4])[CH3:3]

Komponenten

6

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086186Methyl 3-{[isobutyl(methyl)amino]methyl}-5-methylbenzoate

Produkt 1

HCID 210858333-{[Isobutyl(methyl)amino]methyl}-5-methylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 3-{[isobutyl(methyl)amino]methyl}-5-methylbenzoate (120 mg, 0.48 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (200 mg, 4.8 mmol), and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound. ESI MS m/z 236 [M+H]+.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-65e577380f604070a60f53b53a12c787
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

Verknüpfte Notizen

Wird geladen…