Water → 3-{[(tert-Butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoic Acid

HRID 14144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 14144
[C:1]([O:5][C:6]([N:8]([CH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[C:17]([O:19]C)=[O:18])[CH2:9][CH2:10][CH2:11][CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Li+]>CO.O1CCCC1>[C:1]([O:5][C:6]([N:8]([CH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[C:22]([CH3:24])[CH:23]=1)[C:17]([OH:19])=[O:18])[CH2:9][CH2:10][CH2:11][CH3:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

6

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086193HCID 21086193, Verbindung

Produkt 1

HCID 210858673-{[(tert-Butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 3-{[(tert -butoxycarbonyl)(butyl)amino]methyl}-5-methylbenzoate (70 mg, 0.21 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (88 mg, 2.1 mmol), and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e75fcc1cc8834dd5a9f293fa26fd6f2f
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

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