8-Methyl-7-nitroquinoline → HCID 14115670, Verbindung

HRID 1416897Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1416897
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:12][C:3]1[C:2]([CH3:1])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 2541658-Methyl-7-nitroquinolineHCID 2723923Ammonium formate

Produkt 1

HCID 14115670HCID 14115670, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 8-methyl-7-nitroquinoline (1.8 g) in methanol (20 mL) is added palladium-on-carbon (10%, 0.45 g) and ammonium formate (2.77 g). The mixture is stirred at room temperature for 30 minutes, then filtered on Celite, with a methanol wash of the solids. The filtrate is rotary evaporated and the residue partitioned between water and methylene chloride. The organic layer is dried over potassium carbonate, filtered and rotary evaporated to afford 7-amino-8-methylquinoline as a yellow solid.

Aufarbeitung

  1. filtrationfiltered on Celite, with a methanol
  2. washwash of the solids
  3. customThe filtrate is rotary evaporated
  4. customthe residue partitioned between water and methylene chloride
  5. dry with materialThe organic layer is dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

Quellen und Nachweise

ORD-Eintrag
ord-b220c06f3c6042068270816a5513ab96
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05916900

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