4-Methylmorpholine → 8-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

HRID 1417419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1417419
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN1CCOCC1.Cl.CN(C)CCCN=C=NCC.Cl.[CH3:39][NH:40][CH2:41][CH2:42][CH2:43][CH3:44].O.OC1C2N=NNC=2C=CC=1>ClCCl.O>[CH3:39][N:40]([CH2:41][CH2:42][CH2:43][CH3:44])[C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7]

Komponenten

8

Edukt 5

HCID 79724-MethylmorpholineHCID 5462158-(((Tert-butoxy)carbonyl)amino)octanoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 6337757N-methylbutylamine hydrochlorideHCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Combine 8-(t-butoxycarbonyl)amino-octanoic acid (1.28 g, 5 mmol), N-methylmorpholine (1.2 mL, 10 mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride salt (0.95 g, 5.0 mmol), methyl-butyl amine hydrochloride salt (5.0 mmol), and 4-hydroxybenztriazole hydrate (0.05 g) in dichloromethane (20 mL). After 4 hours, add water and extract with ethyl acetate. Dry the organic layer over MgSO4 and evaporate in vacuo to give the title compound.

Aufarbeitung

  1. extractionextract with ethyl acetate
  2. dry with materialDry the organic layer over MgSO4
  3. customevaporate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d97eb11b1d854ecfac8ea4633b8374a2
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05877202

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