Hydrochloric Acid → methyl 4-iodo-1H-indole-6-carboxylate

HRID 14176

Reaktionsgleichung

Reaktionsgleichung von HRID 14176
N[C:2]1[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.Cl.N([O-])=O.[Na+].[I-:20].[Na+]>O>[I:20][C:2]1[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 5238Sodium IodideHCID 14243967Methyl 4-amino-1H-indole-6-carboxylateHCID 23668193Sodium Nitrite

Produkt 1

HCID 851585methyl 4-iodo-1H-indole-6-carboxylateAusbeute 16,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel3×

Versuchsvorschrift

To a mixture of methyl 4-amino-1H-indole-6-carboxylate (Example SP-216, step 3) (3.2 g) in water (50 mL) was added concentrated hydrochloric acid (5 mL). The mixture was chilled to below 5° C. with the addition of ice. To this was added sodium nitrite (1.16 g) dissolved in water (10 mL). The mixture was stirred chilled for 1 h followed by addition of sodium iodide (3 g) in water (20 mL). The mixture was stirred for 30 minutes, filtered and the solids collected by filtration were washed with water and dried at 50° C. The solids turned black and gas evolved rapidly upon drying. Column chromatography on silica gel (200 mL) using 20% hexanes in CH2Cl2 as eluent to give 0.82 g of the title compound: 1H NMR (CDCl3) δ 3.94, 6.55, 7.43, 8.14, 8.22, 8.62.

Aufarbeitung

  1. temperatureThe mixture was chilled to below 5° C. with the addition of ice
  2. temperaturechilled for 1 h
  3. stirringThe mixture was stirred for 30 minutes
  4. filtrationfiltered
  5. filtrationthe solids collected by filtration
  6. washwere washed with water
  7. customdried at 50° C
  8. customupon drying

Quellen und Nachweise

ORD-Eintrag
ord-4a4fc572635c43e4a21bbb4012829dea
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

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