Carbon Dioxide → HCID 178516780, Verbindung

HRID 1419483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1419483
NC[C:3]([C:5]1[N:6]=[CH:7][N:8]([C@@H:15]2[O:20][C@H:19]([CH2:21][OH:22])[C@@H:17]([OH:18])[C@H:16]2[F:23])[C:9]=1[N:10]=[CH:11][N:12](C)[CH3:13])=[O:4].C[O-].[Na+].C(=O)=O>CO>[F:23][C@@H:16]1[C@H:17]([OH:18])[C@@H:19]([CH2:21][OH:22])[O:20][C@H:15]1[N:8]1[C:9]2[N:10]=[CH:11][NH:12][CH2:13][C:3](=[O:4])[C:5]=2[N:6]=[CH:7]1

Komponenten

5

Edukt 3

HCID 280Carbon DioxideHCID 10942334Sodium MethoxideHCID 537945224-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole

Produkt 1

HCID 178516780HCID 178516780, VerbindungAusbeute 36 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

The compound (24) (20 mg) obtained in item (13) above was dissolved in methanol (0.4 ml), to which was added a 0.2M sodium methylate solution (0.4 ml) in methanol and the resulting mixture was allowed to stand at room temperature overnight. The reaction solution obtained was neutralized with addition of dry ice, then concentrated to leave a residue and the residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1), affording the titled compound (25) (6.2 mg) as a colorless solid. Yield: 36%.

Aufarbeitung

  1. customThe reaction solution obtained
  2. concentrationconcentrated
  3. customto leave a residue
  4. customthe residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1)

Quellen und Nachweise

ORD-Eintrag
ord-9d6120a78bae44259dfc44240380669a
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05886167

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