Ethanol → 4-[(5-Fluoro-2-methylbenzoyl)amino]benzoic acid

HRID 1420039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1420039
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:11]=1)=[O:8].[OH-].[Na+].O.C(O)C>C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:14]([OH:16])=[O:15])=[CH:19][CH:20]=1)=[O:8]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 21837152Ethyl 4-[(5-fluoro-2-methylbenzoyl)amino]benzoate

Produkt 1

HCID 218370704-[(5-Fluoro-2-methylbenzoyl)amino]benzoic acidAusbeute 86,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 0.60 g of ethyl 4-[(5-fluoro-2-methylbenzoyl)amino]benzoate 0.60 ml of 10N NaOH, 25 ml of water and 50 ml of absolute ethyl alcohol is heated on a steam bath for 1 hour, cooled and acidified with acetic acid. The resulting solid is filtered and dried in vacuo at 60°-80° C. to give 0.47 g of the desired product as a solid, m.p. 272°-275° C.

Aufarbeitung

  1. temperatureis heated on a steam bath for 1 hour
  2. temperaturecooled
  3. filtrationThe resulting solid is filtered
  4. customdried in vacuo at 60°-80° C.

Quellen und Nachweise

ORD-Eintrag
ord-3cc2be7f3a1e4867b9557cf499a9db5f
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05889001

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