4-Bromophenol → p-Bromophenyl propionate

HRID 1420751

Reaktionsgleichung

Reaktionsgleichung von HRID 1420751
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:19])[CH2:17][CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[C:16]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:19])[CH2:17][CH3:18]

Komponenten

6

Edukt 3

HCID 78084-BromophenolHCID 8471TriethylamineHCID 62324Propionyl chloride

Produkt 1

HCID 90205p-Bromophenyl propionate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Bromophenol (259 g) and 4-dimethylaminopyridine (1.5 g) were dissolved in dichloromethane (1000 ml), the solution was cooled in an ice bath and triethylamine (219 ml) was added portionwise such that the reaction temperature was kept below 20° C. Propionyl chloride (137 ml) was then added over 1 hour and the resulting mixture was stirred at room temperature for 2 hours. The mixture was washed with water followed by brine, then dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 4-bromophenyl propionate (344 g) as a green oil.

Aufarbeitung

  1. temperaturethe solution was cooled in an ice bath
  2. customwas kept below 20° C
  3. washThe mixture was washed with water
  4. dry with materialdried (anhydrous magnesium sulphate)
  5. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-da8fdcec4c6a4e39998f08b7090c8fe6
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06071938

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