Lithium hydroxide, monohydrate → HCID 18706397, Verbindung

HRID 1422225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1422225
C([O:3][C:4](=[O:21])[C:5]([S:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[O:6])C.O.[OH-].[Li+]>O1CCCC1.O>[Br:19][C:17]1[CH:16]=[C:15]2[C:10]([NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[C:9]([CH2:8][S:7][C:5](=[O:6])[C:4]([OH:21])=[O:3])[CH:18]=1

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 86755474HCID 86755474, Verbindung

Produkt 1

HCID 18706397HCID 18706397, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

500 mg (1.34 mmol) of 7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethylsulfanylacetic acid ethyl ester (Example 18) are suspended in 20 ml of tetrahydrofuran and 10 ml of water, and 225 mg (4 equiv.) of lithium hydroxide hydrate are added. The mixture is stirred at 20° C. for 48 hours. The tetrahydrofuran is concentrated by evaporation, 60 ml of water are added and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

Aufarbeitung

  1. concentrationThe tetrahydrofuran is concentrated by evaporation, 60 ml of water
  2. additionare added
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-47cfb5837d8d4fdb906f857fea5a6755
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06080743

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