Acetic Acid → HCID 86688152, Verbindung

HRID 1428947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1428947
[OH-].[Na+].[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([CH3:17])[CH:11]=2)[N:7]=[C:6]1CC#N)[CH3:4].[C:21]([OH:24])(=[O:23])[CH3:22]>O.CS(C)=O>[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([CH3:17])[CH:11]=2)[N:7]=[C:6]1[CH2:22][C:21]([OH:24])=[O:23])[CH3:4]

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 86688150HCID 86688150, Verbindung

Produkt 1

HCID 86688152HCID 86688152, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

930 mg sodium hydroxide in 6 mL water was added to 525 mg (1-ethyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl)-acetonitrile in 2 mL DMSO. The reaction was stirred 4 h at 100° C. The mixture was diluted with water acidified with concentrated acetic acid and extracted with ethylacetate. The organic layer was dried and evaporated. The residue was crystallized with diethyl ether to give 60 mg of the desired product. Rt: 0.94 min (method K), (M+H)+: 263

Aufarbeitung

  1. extractionextracted with ethylacetate
  2. customThe organic layer was dried
  3. customevaporated
  4. customThe residue was crystallized with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-021db7d8c19245cfb368aeb748acb1f2
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937176B2

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