Acetic Acid → 2-Amino-4-(4-morpholinyl)benzonitrile

HRID 1431290

Reaktionsgleichung

Reaktionsgleichung von HRID 1431290
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N+:15]([O-])=O)[CH:8]=2)[CH2:3][CH2:2]1.C(O)(=O)C>[Zn]>[NH2:15][C:9]1[CH:8]=[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 134992654-Morpholino-2-nitrobenzonitrile

Produkt 1

HCID 134992832-Amino-4-(4-morpholinyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23994ZincKatalysator

Versuchsvorschrift

To a mixture of 4-morpholino-2-nitrobenzonitrile (388 mg, 1664 μmol) in acetic acid (6.00 mL, 104809 μmol) at rt was added all at once zinc powder (1632 mg, 24955 μmol). An exotherm developed. The reaction was stirred at ambient temperature for 2 h then filtered, and rinsed with EtOAc. The filtrate was concd under reduced pressure to afford a slightly yellow solid. Mass Spectrum (ESI) m/e=204.1 (M+1).

Aufarbeitung

  1. filtrationthen filtered
  2. washrinsed with EtOAc
  3. customto afford a slightly yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-6f4a4057ac604783850ee04112a798f7
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940724B2

Verknüpfte Notizen

Wird geladen…