Hydrochloric Acid → N-(2,6-dichloro-4-cyanophenyl)acetamide

HRID 1432073

Reaktionsgleichung

Reaktionsgleichung von HRID 1432073
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:11])[C:9]=1[NH2:10])[C:5]#[N:6].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[C:22](Cl)(=[O:24])[CH3:23].Cl>C1COCC1.O.C(Cl)Cl>[C:22]([NH:10][C:9]1[C:2]([Cl:1])=[CH:3][C:4]([C:5]#[N:6])=[CH:7][C:8]=1[Cl:11])(=[O:24])[CH3:23]

Komponenten

8

Edukt 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 5227064-Amino-3,5-dichlorobenzonitrileHCID 2724254Sodium bis(trimethylsilyl)amide

Produkt 1

HCID 2735977N-(2,6-dichloro-4-cyanophenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Step AT1. To a solution of 3,5-dichloro-4-amino-benzonitrile (187 mg, 1 mmol) in 4 mL of THF at room temperature was added 2.2 mL of 1.0 M NaHMDS in THF. The resulting reaction mixture was stirred at room temperature for 30 min., at which time acetyl chloride (3.1 mmol) was added. DCM (100 mL) and water (100 mL) were added to the reaction mixture after being stirred overnight, followed by the addition of 5 mL of 1.4 N HCl aqueous solution. Layers were separated and the aqueous layer was extracted with DCM (2×100 mL). The extracts were combined and solvents were evaporated in vacuo. The residue was purified by HPLC to give 4-acetamido-3,5-dichloro-benzonitrile.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. additionwas added
  3. customLayers were separated
  4. extractionthe aqueous layer was extracted with DCM (2×100 mL)
  5. customsolvents were evaporated in vacuo
  6. customThe residue was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-46d39d059dab474da8c8e5ddd82a93c6
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612069B2

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