1,2-Dichloroethane → N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

HRID 1432552

Reaktionsgleichung

Reaktionsgleichung von HRID 1432552
ClC1C=CC(NC([C:11]2[S:19][C:18]3[CH2:17][CH:16]([C:20]([OH:22])=O)[NH:15][CH2:14][C:13]=3[CH:12]=2)=O)=CC=1.[CH3:23][N:24]1[CH2:28][CH2:27][N:26]=[C:25]1[C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1.[CH2:36]([Cl:39])[CH2:37]Cl.[OH2:40]>CN(C=O)C>[CH3:23][N:24]1[CH2:28][CH2:27][N:26]=[C:25]1[C:29]1[CH:34]=[CH:33][C:32]([NH:35][C:20]([CH:16]2[N:15]([C:14]([NH:15][C:16]3[CH:20]=[CH:37][C:36]([Cl:39])=[CH:18][CH:17]=3)=[O:40])[CH2:14][C:13]3[CH:12]=[CH:11][S:19][C:18]=3[CH2:17]2)=[O:22])=[CH:31][CH:30]=1

Komponenten

6

Edukt 4

HCID 111,2-DichloroethaneHCID 962WaterHCID 227288764-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamineHCID 131727718(4-Chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid

Produkt 1

HCID 11526092N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid (40 mg, 0.12 mmol) and 4-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine (42 mg, 0.24 mmol) in DMF (3 mL) and H2O (0.5 mL) at room temperature, EDC (68 mg, 0.35 mmol) was added. The mixture was stirred at room temperature overnight. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (25 mg). MS 494.3 and 496.3 (M+H, Cl pattern).

Aufarbeitung

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-cfea6a67daa64563ab23c6c906a058a3
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612089B2

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