Diethyl Oxalate → 4-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

HRID 1436084

Reaktionsgleichung

Reaktionsgleichung von HRID 1436084
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][NH:6]CCO.[C:15]([O:22][CH2:23][CH3:24])(=[O:21])[C:16]([O:18]CC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][N:6]1[CH2:24][CH2:23][O:22][C:15](=[O:21])[C:16]1=[O:18]

Komponenten

3

Edukt 2

HCID 7268Diethyl OxalateHCID 63050512HCID 63050512, Verbindung

Produkt 1

HCID 690103374-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additiona diethyl ether was added to the residue
  3. filtrationThe precipitated crystals were collected by filtration
  4. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-94e074c546c94546a00db6bf96662b77
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618960B2

Verknüpfte Notizen

Wird geladen…