1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 4-Hydroxyquinoline-6-carbonitrile

HRID 1437387Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1437387
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)C(=O)O1.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>CCOCC>[O:8]=[C:6]1[C:12]2[C:11](=[CH:18][CH:17]=[C:14]([C:15]#[N:16])[CH:13]=2)[NH:10][CH:9]=[CH:5]1

Komponenten

4

Edukt 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 116947054-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

Produkt 1

HCID 116583514-Hydroxyquinoline-6-carbonitrileAusbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Benzonitrile (a) (27.5 g) was added portionwise over 5 minutes to refluxing Dowtherm A (200 ml). After refluxing an additional 5 minutes, the mixture was allowed to cool to room temperature and diluted with ether (200 ml) with stirring. The product was filtered off, washed thoroughly with ether and air dried to provide a gold solid (16.2 g, 94%).

Aufarbeitung

  1. temperatureAfter refluxing an additional 5 minutes
  2. filtrationThe product was filtered off
  3. washwashed thoroughly with ether and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3be0c4741a29485f881d876f25db75a7
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07622481B2

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