Lithium hydroxide, monohydrate → lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1437777

Reaktionsgleichung

Reaktionsgleichung von HRID 1437777
C[O:2][C:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)=[O:4].O.[OH-].[Li+:14]>CO.O>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C:3]([O-:4])=[O:2])[CH2:9][O:8]1.[Li+:14]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Produkt 1

HCID 67153178lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylateAusbeute 96,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester (5.0 g, 31.25 mmol) in MeOH (32.0 mL) at room temperature was added a solution of lithium hydroxide monohydrate (1.31 g, 31.25 mmol) in water (10.0 mL). The resulting mixture was stirred for thirty min before it was concentrated. The resulting white solid was further dried under vacuum to give the title compound (4.59 g).

Aufarbeitung

  1. concentrationwas concentrated
  2. customThe resulting white solid was further dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-75ba41d0472b4446a9fb0b2800a59c76
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07622508B2

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