Methanol → 4-(Benzyloxy)-3,5-diphenyl-1H-pyrazole

HRID 1439128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1439128
[C:1]1([C:7]2[C:11]([OH:12])=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].CO.[CH2:24](Cl)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O>[CH2:24]([O:12][C:11]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8][NH:9][C:10]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Komponenten

6

Edukt 4

HCID 887MethanolHCID 7503Benzyl ChlorideHCID 3149543,5-diphenyl-1H-pyrazol-4-olHCID 10942334Sodium Methoxide

Produkt 1

HCID 213980924-(Benzyloxy)-3,5-diphenyl-1H-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 3,5-diphenyl-4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60° C for 2 hours. Then benzyl chloride is added slowly at 60° C. A white solid forms. Heating is continued overnight at 60° C. The reaction mixture is examined by glc and the reaction is found to be complete. The mixture is poured into water and the solid isolated by filtration. The solid is washed well with water, dried and recrystallized from acetonitrile to give pale yellow crystals, melting point 152°-152.5° C.

Aufarbeitung

  1. temperatureHeating
  2. customthe solid isolated by filtration
  3. washThe solid is washed well with water
  4. customdried
  5. customrecrystallized from acetonitrile
  6. customto give pale yellow crystals, melting point 152°-152.5° C.

Quellen und Nachweise

ORD-Eintrag
ord-881d88f6676a4942aa53c201bce4b156
Quelldatensatz
uspto-grants-1977_11
Patentnummer
US04058391

Notizen zur Reaktion

Wird geladen…