[C:1]([N:18](C)[C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(N(C)[C@H](C(O)=O)CC(=O)OC(C)(C)C)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.[NH:62](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:63]([C:68]([OH:70])=[O:69])[CH2:64][CH2:65][CH2:66][CH3:67].[NH:88](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:89]([C:100]([OH:102])=[O:101])[CH2:90][C:91]1[C:99]2[C:94](=[CH:95][CH:96]=[CH:97][CH:98]=2)[NH:93][CH:92]=1.N(C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)CC(O)=O>>[NH2:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH:18]([CH3:1])[C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH2:62][C@H:63]([C:68]([OH:70])=[O:69])[CH2:64][CH2:65][CH2:66][CH3:67].[NH2:88][C@H:89]([C:100]([OH:102])=[O:101])[CH2:90][C:91]1[C:99]2[C:94](=[CH:95][CH:96]=[CH:97][CH:98]=2)[NH:93][CH:92]=1By following essentially the procedure of Table 2 and sequentially coupling Fmoc-MePhe-OH, Fmoc-MeAsp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Ahx-OH and Hpa-OSu, the title compound was prepared. Amino Acid analysis following acid decomposition gave MeAsp 1.01 (1), Gly 1.05 (1), MePhe 0.91 (1), Ahx 2.02 (2), Trp 0.84 (1), NH3 0.82. MS (FAB): m/e 909 (M-H)-.
Wird geladen…