1-methyl-5-nitro-2(1H)-pyridinone → 5-Amino-1-methyl-1,2-dihydropyridin-2-one

HRID 1441731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1441731
[CH3:1][N:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]1=[O:11]>CO.CC(O)=O.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3](=[O:11])[N:2]([CH3:1])[CH:7]=1

Komponenten

5

Edukt 1

HCID 2958661-methyl-5-nitro-2(1H)-pyridinone

Produkt 1

HCID 102200055-Amino-1-methyl-1,2-dihydropyridin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of compound 50B (200 mg, 1.298 mmol) and 10% Pd/C (˜5 mg) in MeOH and AcOH was stirred under H2 at 1 atmosphere for 30 minutes. The reaction solution was filtered through a pad of celite eluting with MeOH. The MeOH was removed under reduced pressure to give compound 50C.

Aufarbeitung

  1. filtrationThe reaction solution was filtered through a pad of celite
  2. washeluting with MeOH
  3. customThe MeOH was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6bff92f6f0fa413cbb9b190ca49314cb
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07655688B2

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