Acetic Acid → 4-Amino-6-fluoroisoindolin-1-one

HRID 1443140Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1443140
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([N+:11]([O-])=O)[C:5]=1[CH2:14][N:15]=[N+]=[N-].C(O)(=O)C>C(O)C.[Pd]>[NH2:11][C:6]1[CH:7]=[C:8]([F:10])[CH:9]=[C:4]2[C:5]=1[CH2:14][NH:15][C:3]2=[O:2]

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 860442842-(Azidomethyl)-5-fluoro-3-nitrobenzoic Acid Methyl Ester

Produkt 1

HCID 179850484-Amino-6-fluoroisoindolin-1-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1.86 g (7.32 mmol) of 2-(azidomethyl)-5-fluoro-3-nitrobenzoic acid methyl ester is added in 46 ml of ethanol and 3.4 ml of glacial acetic acid and mixed with 256.6 mg of Pd/C. After stirring overnight at room temperature under a hydrogen atmosphere, the catalyst is suctioned off via a glass fiber filter, and the filtrate is evaporated to the dry state. The residue, 1.18 mg (97.5%) of the desired compound, is further incorporated in crude form.

Aufarbeitung

  1. filtrationfilter
  2. customthe filtrate is evaporated to the dry state

Quellen und Nachweise

ORD-Eintrag
ord-669a77a4431b4592996a875b7eb59dff
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659297B2

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