Hydrogen Bromide → HCID 20550939, Verbindung

HRID 1447419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1447419
[C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)(=[O:3])[CH3:2].[BrH:12].BrBr>C(Cl)(Cl)Cl.C(O)(=O)C>[Br:12][CH2:2][C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)=[O:3]

Komponenten

6

Edukt 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 205509375-Acetylthiophene-3-carboxamide

Produkt 1

HCID 20550939HCID 20550939, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidKatalysatorHCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

A solution of 5-acetylthiophene-3-carboxamide (0.5 g) in chloroform at 50° was treated with hydrogen bromide in acetic acid (4 drops) and then bromine (0.15 ml) in chloroform (10 ml) dropwise over 30 min. The resulting pale yellow solution was washed with water (2×100 ml), dried and evaporated to small volume to deposit the title compound as a white solid (0.55 g) which recrystallised from water, m.p. 150°-157° (d).

Aufarbeitung

  1. washThe resulting pale yellow solution was washed with water (2×100 ml)
  2. customdried
  3. customevaporated to small volume
  4. customrecrystallised from water, m.p. 150°-157° (d)

Quellen und Nachweise

ORD-Eintrag
ord-e37ce2377dc84078a3014aa9c3f5b49e
Quelldatensatz
uspto-grants-1982_02
Patentnummer
US04316907

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