Diethyl Ether → L-alanyl-L-proline n-pentylamide

HRID 1448745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1448745
[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH:15]C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][CH2:4][CH3:5].CCOCC>Br.C(O)(=O)C>[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH2:15])[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

5

Edukt 2

HCID 3283Diethyl EtherHCID 53667817HCID 53667817, Verbindung

Produkt 1

HCID 54383360L-alanyl-L-proline n-pentylamideAusbeute 152,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 260Hydrogen BromideLösungsmittel

Versuchsvorschrift

2.5 g of N-benzyloxycarbonyl-L-alanyl-L-proline n-pentylamide were dissolved in 15 ml of 4-N hydrogen bromide in acetic acid and the solution was stirred for 1 hour at room temperature. 150 ml of dry ether were added. An oil precipitated out and was allowed to settle. The ether was decanted off and the procedure repeated using 150 ml of fresh ether. On evaporation there were obtained 2.5 g of L-alanyl-L-proline n-pentylamide in the form of a white solid.

Aufarbeitung

  1. customAn oil precipitated out
  2. customThe ether was decanted off
  3. customOn evaporation there

Quellen und Nachweise

ORD-Eintrag
ord-f1c080d621b844b1b64286a577ad7823
Quelldatensatz
uspto-grants-1980_02
Patentnummer
US04187216

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